FRONTLINE COMBO 40-60 KG 3 PIPETTES | External antiparasitic in topical solution

FRONTLINE COMBO 

FRONTLINE COMBO SPOT-ON DOG

External antiparasitic in topical solution

Pharmaceutical form Spot-on dorsal anointing solution (Sol.udp)

Composition::- 0,67 ml pipette: Fipronil 67 mg; (S)-methoprene 60,30 mg; butylated hydroxyanisole (E 320) 0,13 mg; butylated hydroxytoluene (E 321) 0,07 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.

– 1,34 ml pipette: Fipronil 134 mg; (S)-methoprene 120,6 mg; butylated hydroxyanisole (E 320) 0,27 mg; butylated hydroxytoluene (E 321) 0,13 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.

– 2,68 ml pipette: Fipronil 268 mg; (S)-methoprene 241,2 mg; butylated hydroxyanisole (E 320) 0,54 mg; butylated hydroxytoluene (E 321) 0,27 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.

– 4,02 ml pipette: Fipronil 402 mg; (S)-methoprene 361,8 mg; butylated hydroxyanisole (E 320) 0,8 mg; butylated hydroxytoluene (E 321) 0,4 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.

Pharmacological properties

The product is an insecticidal, acaricidal solution for topical use that contains an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

Fipronil is an insecticide/miticide that belongs to the phenylpyrazole family. It works by interacting with ligand-gated chloride channels.

(S)-Methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects.

Interactions and incompatibilities

None known.

Indications

Dogs: The product can be used against flea infestations, alone or associated with ticks and/or biting lice.

– Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new infestations by adult fleas persists for 8 weeks. Prevention of flea multiplication by inhibition of the development of eggs (ovicidal activity) and of larvae and pupae (larvicidal activity) generated from eggs laid by adult fleas for 8 weeks after application.

– Elimination of ticks (Ixodes ricinus, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus). The product has an acaricidal efficacy in dogs that persists for up to 4 weeks against ticks.

– Elimination of biting lice (Trichodectes canis).

The product can be used as part of the treatment strategy for the control of flea allergy dermatitis (FAD).

It can be used during pregnancy and lactation.

Contraindications

In the absence of available data, the product should not be used in puppies less than 8 weeks of age and/or puppies weighing less than 2 kg.

Do not use in sick animals (systemic disease, fever...) or convalescents.

Do not use in rabbits.

Do not use the presentations intended for dogs in cats, as this could lead to overdose.

Adverse reactions

Very rare reactions reported after use of the product include: transient skin reactions at the point of application (skin discoloration, local hair loss, itching, redness) as well as general itching or hair loss . After administration of the drug, excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting, or respiratory symptoms have also been observed.

In case of licking, a brief period of excessive salivation may be observed mainly due to the nature of the excipient.

Administer the recommended dose.

No adverse reactions have been observed in safety studies conducted in the target species, in puppies from 8 weeks of age, growing dogs, and dogs weighing approximately 2 kg treated at once to five times the recommended dose. The risk of adverse reactions may however be increased when overdosed, therefore animals should always be treated with the correct pipette size corresponding to their body weight.

Route of administration

Topical on the skin.

Posology

Dogs: The dosage corresponding to the minimum recommended dose is 6,7 mg/kg of fipronil and 6 mg/kg of (S)-methoprene, by topical application on the skin. So:

– One 0,67 ml pipette Frontline Combo Spot-on Dogs 2-10 kg per dog over 2 kg up to 10 kg bw

– One 1,34 ml pipette Frontline Combo Spot-on Dogs 10-20 kg per dog over 10 kg up to 20 kg bw

– One 2,68 ml pipette Frontline Combo Spot-on Dogs 20-40 kg per dog over 20 kg up to 40 kg bw

– One 4,02 ml pipette Frontline Combo Spot-on Dogs >40 kg per dog over 40 kg bw

In the absence of safety studies, the minimum treatment interval is 4 weeks.

Method of administration:

Keep the pipette upright. Tap the narrow part of the pipet to ensure that all contents remain within the main body of the pipet.

Break the tip of the pipette with a sharp gesture towards the back.

Part the fur on the back of the animal at the base of the neck, in front of the shoulder blades, until the skin is visible.

Place the tip of the pipette on the skin and squeeze the pipette several times to completely empty its contents directly on the skin in a spot.

Do not smoke, eat or drink during the application.

Frontline Combo Spot-on Dog can be used during pregnancy and lactation.

Wait time

Not applicable.

conservation mode

Do not store at temperatures above 30 °C. Store in the original container.

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